Sheetrock Hills Citizens
Manuel "Manny" Garcia: Wilmer Valderrama
Kelly the owner of the Hardware Store: Nancy Truman
Mr. Leonard Francis Lopart: Tom Kenny
Kelly's younger brother, Elliot: Lance Bass
Mrs. Portillo: Shelley Morrison
Señor Sanchez and his Granddaughter Julieta: Isabella Pajaro
Mr. Lopart's mom, Mrs. Lopart: Marion Ross
Manny's older sister, Lola: Annie Mumolo
Manny's nephew, Pepe: Elan Garfias
Manny's nephew, Chico: Mandy Burbano
Mr. Lopart's nephew, Lyle Lopart: Cooper Green
Mr. Lopart's nephew, Lyle's twin brother, Leland Lopart: Benjamin Brian
Mayor Rosa
Manny's Abeulito
Manny's ex-girlfriend, Carmella Covarrubias
The Tools
Felipe a Phillips Screwdriver: Carlos Alazraqui
Turner a Flathead Screwdriver: Dee Bradley Baker
Stretch a Tape measure: Nika Futterman
Squeeze a pair of Pliers: Nika Futterman
Pat the Hammer: Tom Kenny
Dusty a Saw: Kath Soucie
Rusty a Monkey wrench: Fred Stoller
Flicker a flashlight: Grey DeLisle
The Seville Family
Mandy Seville: Me
Mandy's mother, Daveena Seville: Terri Irwin
Mandy's father, David "Dave" Seville: Jason Lee
Mandy's favorite uncle, Tarrance Hightopp: Johnny Depp
Mandy's favorite uncle, Tarrance's twin brother, John Robert Hoffman
Mandy's older brother, Will Seville: Wesley Eure
Mandy's older brother, Kirklynd Seville: Kirk Fairbanks Fogg
Mandy's older brother, Jaycent Seville: Jason Harris Katz
Mandy's older sister, Serafina Seville: Summer Elisabeth Sanders
Mandy's older brother, Donovan Seville: David Ross Aizer
Mandy's adopted younger brother, Alvin Seville (speaking voice): Justin Long
Mandy's adopted younger brother, Simon Seville (speaking voice): Matthew Gray Gubler
Mandy's adopted younger brother, Theodore Seville (speaking voice): Jesse McCartney
Mandy's adopted younger brother, Alvin Seville (singing voice): Ross Bagdasarian, Jr.
Mandy's adopted younger brother, Simon Seville (singing voice): Steve Vining
Mandy's adopted younger brother, Theodore Seville (singing voice): Janice Karman
Alvin's girlfriend, Brittany Miller (speaking voice): Christina Applegate
Simon's girlfriend, Jeanette Miller (speaking voice): Anna Faris
Theodore's girlfriend, Eleanor Miller (speaking voice): Amy Poehler
The Chipettes (singing voices): Janice Karman
Manuel "Manny" Garcia: Wilmer Valderrama
Kelly the owner of the Hardware Store: Nancy Truman
Mr. Leonard Francis Lopart: Tom Kenny
Kelly's younger brother, Elliot: Lance Bass
Mrs. Portillo: Shelley Morrison
Señor Sanchez and his Granddaughter Julieta: Isabella Pajaro
Mr. Lopart's mom, Mrs. Lopart: Marion Ross
Manny's older sister, Lola: Annie Mumolo
Manny's nephew, Pepe: Elan Garfias
Manny's nephew, Chico: Mandy Burbano
Mr. Lopart's nephew, Lyle Lopart: Cooper Green
Mr. Lopart's nephew, Lyle's twin brother, Leland Lopart: Benjamin Brian
Mayor Rosa
Manny's Abeulito
Manny's ex-girlfriend, Carmella Covarrubias
The Tools
Felipe a Phillips Screwdriver: Carlos Alazraqui
Turner a Flathead Screwdriver: Dee Bradley Baker
Stretch a Tape measure: Nika Futterman
Squeeze a pair of Pliers: Nika Futterman
Pat the Hammer: Tom Kenny
Dusty a Saw: Kath Soucie
Rusty a Monkey wrench: Fred Stoller
Flicker a flashlight: Grey DeLisle
The Seville Family
Mandy Seville: Me
Mandy's mother, Daveena Seville: Terri Irwin
Mandy's father, David "Dave" Seville: Jason Lee
Mandy's favorite uncle, Tarrance Hightopp: Johnny Depp
Mandy's favorite uncle, Tarrance's twin brother, John Robert Hoffman
Mandy's older brother, Will Seville: Wesley Eure
Mandy's older brother, Kirklynd Seville: Kirk Fairbanks Fogg
Mandy's older brother, Jaycent Seville: Jason Harris Katz
Mandy's older sister, Serafina Seville: Summer Elisabeth Sanders
Mandy's older brother, Donovan Seville: David Ross Aizer
Mandy's adopted younger brother, Alvin Seville (speaking voice): Justin Long
Mandy's adopted younger brother, Simon Seville (speaking voice): Matthew Gray Gubler
Mandy's adopted younger brother, Theodore Seville (speaking voice): Jesse McCartney
Mandy's adopted younger brother, Alvin Seville (singing voice): Ross Bagdasarian, Jr.
Mandy's adopted younger brother, Simon Seville (singing voice): Steve Vining
Mandy's adopted younger brother, Theodore Seville (singing voice): Janice Karman
Alvin's girlfriend, Brittany Miller (speaking voice): Christina Applegate
Simon's girlfriend, Jeanette Miller (speaking voice): Anna Faris
Theodore's girlfriend, Eleanor Miller (speaking voice): Amy Poehler
The Chipettes (singing voices): Janice Karman